FDA approves ultra-low estrogen patch On June 9th the FDA approved a new ultra-low estrogen patch called Menostar. Here's the relevant info. What's most attractive is this is bioidentical estradiol and you don't have to use prosgesterone of any type because this dose does not stimulate uterine proliferation!! This dose is roughly equivalent to half of a .025 patch. Berlex, the U.S. affiliate of Schering AG, Germany , announced to today that the U.S. Food and Drug Administration (FDA) approved Menostar™ (estradiol transdermal system) 14 micrograms/day, an advancement in osteoporosis prevention in a convenient transdermal patch. This patch delivers such a low dose of plant-derived estrogen that it can be used in women with or without a uterus. Menostar is a clear, dime-sized, once-a-week patch that delivers half the dose-only 14 micrograms per day-of the lowest currently available dose of transdermal estrogen therapy for post-menopausal osteoporosis prevention. Menostar is a fundamentally new approach to post-menopausal osteoporosis prevention. In a two-year clinical study, Menostar, with a very low dose of estrogen, did not increase the risk of endometrial hyperplasia among women with a uterus. Therefore, this patch does not require a daily or monthly concomitant progestin,"(1) said Marie Foegh, M.D., Vice President, Medical Affairs for Berlex Laboratories. "Until now, we in the medical community never knew such small amounts of estrogen could help maintain bone health. With Menostar, we can return a woman's estrogen to the lowest level proven to prevent bone loss." More info at: http://www.pslgroup.com/dg/2445d6.htm