Recently my doctor asked me to decrease my Premarin dose because I now have 2 first degree relatives who have had cancer. I was fine until day 5 when I started facial itching. The next day it was facial flushing with facial and generalized itching and anxiety.I don't know if this is the cause but I suspect it is. I resumed the usual dose of premarin and felt some better, but the anxiety and some itching continue. Has this happened to anyone else? What can be done? I was so calm before. Now I feel like my life has been turned upside down.