QUOTE (Michah Hadley @ May 26 2009, 04:38 PM)

Hi JZZ, yep, I hear you. Thanks for telling me that you are learning to deal with it......I mean I have been living with it for 4 years so I guess it is no different now that I know......but I have done some silly things!! I used to fall into things at work, trip over for no reason and hurt myself. I swear everyone at work thought i was drunk!! And Ibuprofen plus codeine is the only thing that helps with period pain. Otherwise I have to take panadeine forte or Tramadol which are bad for the liver and for some reason with me they don'rt work as well. So I don't know what I am going to do with that.....
Anyway, it will get easier......thanks!!

Michah, Codeine (or any of the morphine derivatives and many many other drugs) are also called "pro drugs". The liver needs to be able to convert a pro drug into the "active" form.....hence (pain relief) as in the case of the morphine family of drugs. My liver lacks a major enzymatic pathway and cannot clear OR convert many drugs. I cannot use morphine but you can. Listen to your body!!! The reason you can't tolerate the other 2 drugs may be a liver clearance and/or conversion issue. Or maybe you need a dosage adjustment.
I almost died 2 years ago from being an incorrect dose of Medication while in the hospital and no one could figure out why. Finally, I had some fairly specialized testing done and we discovered my genetic liver enzyme problem. My entire life I had problems with even tiny amounts of meds and couldn't take them. Now, FINALLY the docs listen to me because I have the test results to back it up with. I get so tired of hearing docs and people say to "just keep taking a med or supplement and their body will adjust." Not always. And the result can be toxic and or life altering. Sorry, I am rambling and an NOT trying to scare you. I just want everyone to make an informed decision and do what works best for their own body.
As one of my favorite docs used to say: "just because something hasn't been studied doesn't mean it doesn't exist (happen)." My liver enzyme problem was very real and no one would listen. Unfortunately it took a major error And a fairly new blood test to PROVE that my lifelong bad reactions to meds was a not to be ignored part of my own physiology.
Feel free to pm me if I can be of help. Best wishes, JZZ