hI LADIES,
JUST WONDERING IF ANY OF YOU ARE TAKING 50/50 BIEST. I JUST RECENTLY CHANGED FROM 80/20 1 MG. PER DAY TO 50/50 1 MG. PER DAY MAINLY TO HELP WITH SLEEP DISTURBANCES. DIFFICULTY FALLING AND STAYING ASLEEP ALMOST TO THE POINT OF CRAZINESS. I CAN'T TOLERATE PROGEST--TRIED CYCLING WITH IT AFTER TWO MONTHS ON THE E BUT HAD TOO MANY GASTRO PROBLEMS. SO QUIT IT AFTER 6 DAYS. I'M SCARED BECAUSE I HAVE MY UTERUS. WAS WONDERING IF 50/50 1 MG. PER DAY IS SUFFICIENT FOR SLEEP ISSUES. ANY INFO WOULD BE APPRECIATED. ALSO FOR THE FIRST TIME SINCE I STARTED THE BIEST I HAVE NOTICED TENDER NIPPLES AND A STRONG VAGINAL ODOR WHICH I NEVER BEFORE EXPERIENCED. ANY FEEDBACK ON THIS? THANKS LADIES

I strongly suspect estriol is the culprit here. I know for a fact it causes tender nipples, it did for me and others here have said the same. And probably the vaginal odor is also due to the estriol.

Have you considered a trial of just plain estradiol? It has helped many of us with sleep and other issues when the Biest did not..

Hi Sariah,
Thanks for the response. I have never tried a trial of just pain estradiol. Does it have to be compounded? Or is there a brand name to order. I started with 80/20 biest (80 percent estriol and 20 percent estradiol) and did not notice any changes in my sleep and like I mentioned experienced the nipple tenderness and vaginal ordor right away. SO-I talked to the pharmacist and she suggested 50/50 biest. So-I am now on day three of this at 1 mg. per day. I wonder if I should try upping it to 2 mg. a day of the 50/50 to see if anything is different. What is your opinion? Thanks sariah!