QUOTE (kackle @ Apr 30 2009, 08:46 AM)

Would you explain cortisol steal adrenal route . All of what you ladies said is so spot on. I've had not yeast issues since being off the progesterone and when coming down on it had insulin reaction and now I'm back to my fibromyalgia symptoms. I'm considering estrogen,after getting more test results back, but I'm wondering if I should use an an otc progesterone cream if and when I start the estrogen. It's confusing.
QUOTE
Many women face decreased levels of progesterone, which is associated with hot flashes, bone loss, PMS, fertility, fatigue, weight gain, insomnia, decreased libido, etc. The problem is pregnenolone and progesterone are being ‘stolen’, to make cortisol. This is very important because in order to make cortisol….the adrenal glands need progesterone. It is one of the raw materials needed to make cortisol
I may add that progesterone is father hormone, while pregnenolone is grandfather, so without E and T , adding progesterone alone can lead to furtgher imbalance. If your adrenals are overworked, as it is very common during perimenopausal years, the progesterone will be used to make corstiol. So if your adrenals are always stealing pregnenolone and progesterone to make cortisol – you may not have enough of those hormones which are needed to make DHEA, estrogen and testosterone.
Our body always takes care of survival, so if there is deficiency, first major hormones will be taken care of, and then minor (sex ) hormones, if there is enough raw material left.
As we approach menopause our ovaries slow down and eventually stop functioning. Now, it is up to our adrenals to produce all estrogen, progesterone, testosterone and DHEA. However, if adrenals are exhausted, how are they supposed to pick up the slack and keep up the same pace as the ovaries? It doesn’t happen… so we end up with anxiety rollercoster and other symptoms...I yet want to see any 40+ male or female with 100% healthy adrenals, consider our poor diets, hectic lives, and enormous amount of stress. Also, it is pretty common that our endocrine glands also weathering out by the time we reach midlife, so they need also enough materil to repair and keep functioning.
here is female hormonal pathways, you can see how T can be covnerted into E, and P can be made into C. etc.
http://www.biodia.com/TechnicalCharts/Ster...ormonechart.pdfBasically, in the absence of Progesterone, the pregnenolone is stolen to make adrenal hormones, so E and T will not be manufactured. Unless you have plenty of E and T already, it is all confusing, but I know one thing, women who make plenty of estrogen, not only estaradiol, but plenty of estrone ( that can be converted to estradiol), can add some P without seeing ill effect, but it is usually only during our reproductive years, and not later in menopausal years, again, not everyone, some continue to produce lots of estrone.
Hope this makes sense, see for yourself.

HTH,
I.