I can't figure it either. I think I had a period, at least a two day spotting thing and I recall being a little itchy before that. I use Prometrium for 14 days a month so not on that right now just a very small dose of Estradiol. Also I have a killer headache but not the usual left sided migraine I usually get once a month, it's different. The itching stopped mostly after a few hours, today it started a little bit, but not as bad as yesterday.
I figure its the fluctuating hormones for sure even though I'm supplementing I think it still jumps around. I've had 3 blood tests looking at the estradiol over 3 months, one time it was 617, then 200 something, then way back down to 27. And I've been using the same dose every day, so how is it that the levels aren't become more stable?
Dr. Vliet says she tests everyone and when their estradiol gets to over 100 and under 200 I think, she keeps them at the dose that is stabilizing that level. Well mine keeps going up, then down, so I'm not sure why. So I think the itchies are for sure the estrogen going dopey again, but it's so annoying. Nothing helps it either.

I hate my 40's.