QUOTE (2sonsmom @ Oct 22 2008, 08:14 PM)

Hi ladies, just wanted you all to know that your prayers have worked once again, my husband came home this afternoon! He had a new stent put in to replace an old one that wore out and he is in rejection but was treated with strong IV drugs so he will have to change his meds for now. His congestive heart failure will be monitored, and treated also with medicine for now. We are very thankful he has made it home and will be able to attend our son's wedding on Nov. 2nd. You have all been so supportive and we appreciate each and every one of you for your kindness and prayers.
hugs,
Barb
Barb,
Great news! Be sure he gets enough CoQ10 (usually 400mg/day)
One Year CoQ10 trial For DCM
1993 - The main problems in CHF patients are frequent hospitalizations, high number of serious arrhythmia, and filling of the lungs with fluid. We studied the effect of long-term CoQ10 on these events in patients with class 3 and 4 CHF taking standard CHF drugs.
Three hundred and twenty-two people with an average age of 67 years were given placebo. Three hundred and nineteen people with an average age of 67 years took CoQ10. The dose was 2mg per kilogram (2.2 lbs) of body weight every day for one year.
The number of patients who needed hospitalization for worsening heart failure was smaller in the CoQ10 group (73) than in the non-CoQ10 group (118). The episodes of lung congestion (20 versus 51 in placebo group) or cardiac asthma (97 vs 198 in placebo group) were also reduced in the CoQ10 group.
Adding CoQ10 to standard drug therapy reduces hospitalizations for worsening heart failure and the number of serious complications in CHF patients.
Title: Effect of COQ10 therapy in patients with congestive heart failure: a long-term multicenter randomized study
Authors: Morisco C, Trimarco B, Condorelli M
ID numbers: PMID: 8241697, MUID: 94060607
Do Sick Hearts Have Less CoQ10?
1993 - CoQ10 is a natural antioxidant. One biochemical reason for treating heart disease with Coq10 was established years ago by Folkers. I proved this with a study of heart tissue from 45 of my cardiomyopathy patients.
Levels of CoQ10 found in "advanced" CHF hearts are much lower than CoQ10 levels found in hearts of patients with "mild" CHF. This deficiency might be corrected by oral supplements.
In this study, taking 100mg CoQ10 daily, nearly 2/3 of patients showed clinical improvement, most pronounced in those with dilated cardiomyopathy. CoQ10 may be a good added treatment in heart failure, with positive effects on patients' outcome, physical activity, and quality of life.
Title: Perspectives on therapy of cardiovascular diseases with COQ10
Author: Mortensen SA
Source: Clin Investig 1993;71(8 Suppl):S116-23
ID numbers: PMID: 8241694, MUID: 94060604
Statins Reduce CoQ10 Level
1994 - The biologic pathway of the CoQ chain is the same as that of cholesterol. We studied whether cholesterol-lowering drugs like Zocor change CoQ10 blood levels. Thirty-four patients with high cholesterol took 20mg of Zocor for 6 months (no-CoQ10 group) or 20mg of Zocor plus 100mg CoQ10 (CoQ10 group). Total cholesterol, HDL, LDL, triglycerides, CoQ10 blood level and more were checked at study start, 45, 90, 135, and 180 days
In the no-CoQ10 group, total cholesterol and LDL went down and so did blood CoQ10 levels. In the CoQ10 group, CoQ10 blood levels increased while cholesterol reduction was similar to the no-CoQ10 group. CoQ10 in blood cells also decreased in the no-CoQ10 group and increased in the CoQ10 group.
Zocor lowers LDL blood levels, blood and blood cell levels of CoQ10. Taking CoQ10 prevents both blood and blood cell CoQ10 reductions without affecting the cholesterol lowering action of Zocor.
If you take a cholesterol-lowering drug like Zocor, you should take extra CoQ10. It won't affect the action of the cholesterol drug. The cholesterol drug is reducing the amount of CoQ10 in your blood and taking extra CoQ10 will make up for it.
Title: Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors
Authors: Bargossi AM; Grossi G; Fiorella PL; Gaddi A; Di Giulio R; Battino M
Source: Mol Aspects Med, 1994, 15 Suppl:, s187-93
ID number: 95272323
The Worse You Are, The Better You'll Get
1990 - We studied CoQ10 use in DCM patients. CoQ10 levels are very low in heart tissue biopsies taken from DCM hearts, compared to normal hearts.
Thirty DCM patients took 100mg CoQ10 per day for 2 months. Before and after treatment, a clinical exam checked heart class and an echo checked ejection fraction. Heart size and filling capacity were tested. Blood was drawn to check CoQ10 levels.
Seven patients left the study because of poor compliance. In 47% of patients, symptoms and heart class improved. The average EF improved from 31% to 37%. Heart size went down. The CoQ10 blood levels went up in 95% of patients to 2.27 micrograms/ml. The more a patient's heart lacked CoQ10 before treatment, the more that patient benefited during this study.
CoQ10 deficiency in DCM may be reversible. The amount of benefit may depend on pre-treatment CoQ10 levels in the blood and heart. CoQ10 should be considered an effective addition to DCM/CHF therapy.
Title: Coenzyme Q10 in dilated cardiomyopathy
Authors: Manzoli U; Rossi E; Littarru GP; Frustaci A; Lippa S; Oradei A; Aureli V
Source: Int J Tissue React, 1990, 12:3, 173-8
ID number: 91115533
cindy