Ensure the cream is of the highest quality. Vaginal tissue is very delicate and sensitive, and can be thin, dry and atrophied, particularly for post-menopausal women. So check with your cream manufacturer or compounding pharmacist that there are no irritants or ingredients that contraindicate this form of usage. Be very gentle using an applicator as it may traumatise vaginal tissue because of the above reasons. Note that women prefer to alternate between vaginal and transdermal delivery for optimal site receptability.
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