The place I seem to feel most of my pain is just inside the vagina, at the bottom. It's that fleshy, bumpy feeling tissue you feel. What exactly is that, and has anyone experienced pain there? Thanks!

Possibly there are more nerve endings in that part of the vagina than further up? I always experienced pain around the entrance and also externally (before using estriol cream).

Can estrogen cream help with nerve ending problems? i started using it on Dec. 1st, and though things are a bit more moister, it really hasn't helped totally with the pain. I do know that estrogen cream takes quite a bit more time to bring things back into balance though.....

Sorry what I meant was that whilst vaginal atrophy probably affects the whole of the vagina and external sexual organs, maybe we feel more pain at the lower end of the vagina and externally because there are a greater concentration of nerve endings in these parts than in the upper part of the vagina. I'm no authority on this, and it would be interesting to ask a doctor, but when applying the cream in these parts using my fingers, rather than the plastic applicator, I noticed that there was more sensation and feeling in the entrance and lower part of the vagina than further up. I'd never noticed before.

I didn't mean that there were problems with the nerve endings or that estriol cream could help with nerve endings, I just meant that in the areas of the body where there are a greater concentration of nerve endings, we have more feeling and sensation and therefore it would make sense to feel pain more in these areas.

I don't know what you're using, but I think the estriol cream is weak compared to the estrogen the body provides prior to menopause. Therefore unless you're supplementing with systemic estrogen, it might not give you the fullness and lubrication you would have had prior to menopause. Like you, I've read on this board that it can take some time to work. I've been using estriol cream for a few months. Since I don't supplement with any other form of estrogen, the initial effects were dramatic in terms of plumping up the area and easing it. However it's nowhere near what it was pre-menopause and I don't expect it ever will be again. Even when I took oral HRT, which provided a much better effect in those parts than the estriol cream I'm using now, it still wasn't as it had been pre-menopause.