I just started bioidenticals a few months ago. I took both estradiol and progesterone by drops. I did notice I developed acne when adding the progesterone. At that time, I used progesterone for 21 days and estradiol daily. Besides the acne, I did not feel wonderful when on P (cranky, bloated/swollen all over).
For this last month, however, my doc switched me to sublingual troches (like gummy bears). I now take 100 mg of P on days 13-27 and estradiol .5 mg daily. I noticed I did not have acne like I had in previous months . I'm not sure if it's the different delivery method, being better balanced this month, cycling or just magic. Symptoms wise, this has been my best month yet.