I have been on Activella for 10 weeks now. I still get an occasional hot flash, still have problems sleeping and still have really bad PVCS. The doctor said a couple of weeks ago that it sometimes takes along time for HRT to work. I also still get horrible PMS and Pre mid-cyle symtoms (crying, palps, etc) Does this mean the Activella is not really working? I am 44 and in peri. Any suggestions? Thanks!