QUOTE (katyq @ Jul 23 2009, 03:03 PM)

I take it at night time. Maybe I should change that around.
I don't take progesterone...something about having a uterus? Not sure why but my Dr said no...he also doesn't believe in bioidentical hormones.
I'm just very concerned...about me.
I went BHRT toute and the exprience was very unpleasant to tell the least, I went to another doctor, and he does not believe in BHRT either, thinking mini pill is much better for perimenopausal women that still cycle, as i do.
For what I understand, the estrogen is not major concern, the progesterone is. Natural progesterone as bioidentical, when not balanced with plenty of estrogen, can increase androgenic and mineralocorticoids (e.g., aldosterone) hormones and this can lead to further imbalance and serious cardio vascular complications if ignored. The type of estrogen is least imporant than the type of progesterone, the best seems to be progestines that don't have androgenic proprties but offer same protection for the uterine lining.
Problem with menopause and peri-menopause, is that when estrogen starts to decline and drops dramatically, we barely need any progesterone, if no symptoms present.
The adrenals, if healthy, will take over, the liver, kidneys, fat cells will aromatize estrogen and everything should be peachy, ideally.
In reality, ovaries don't not shut down overnight, and while anxiety, hot flashes, and other nasty symtoms are due to wild fluctuations of hormones, the rest of the issues linked to estrogen difficiency, not easy to correct with ADs or BZD, supplements, vitamins, and healthy lifestyle.
I did my home work, tried to figure out why BHRT made me feel so bad, and it seems because of progesterone, that blocked the small amount of estrodiol I supplemented with, and gave me anxiety, depression, suicidal thought, fatigue, indigestion, weight gain, etc.
Now I understand why some doctors don't believe in BHRT, becase of the eash body unique ability to convert natural P into adrenal hormones, which causes majority of symptoms.
BHRT if used, it has to be at least, 2 g of estradiol for small amount of progesterone, to feel normal and prevent mental issues and vascular constriction that results in chest pain, heaviness, heavy heart beat, etc.
I read more about European HRTs, seems all formulation contain bioidentical estrodial and one of the syntetic progestines. Prometrium oral and vaginal gel are used mostly for short term, as fertility treatment, and to resolve medical conditions, as heavy bleeding, fibroids, etc.
Hardly it is used as routine and long term HRT with high rate of success.
I seem to get worse anxiety when my own progesterone spikes, as I have low estradiol when checked via blood test, once P drops, I feel much better and calmer, also more energy and less moody.
HTH,
I.