QUOTE (joliejacq @ Mar 28 2007, 06:47 AM)

Hi,
There are many other threads on Power-Surge about this phenomenon - women have been going through it forever! You'd think our doctors would know something about it, if so many of us have struggled so...
I've read that surges happen because the adrenal glands are capable of churning out small amounts of estrogen. When our ovaries start "shutting down," the adrenals attempt to take over, and unfortunately, as they produce these wee amounts, they are also releasing anxiety-provoking chemicals. Talk about a Catch-22!!! This is more apt to happen, unfortunately, in the middle of the night, a time when the adrenals become more active.
Estrogen is also produced in body fat, especially fat that gathers around the belly, which is likely why we gain in that area when we arrive at middle age.
Our bodies ARE trying to find a kind of balance in all this, and we are left just watching what's happening! For me, it's been sooooo reminiscent of adolescence! Mood swings, tears, slamming doors, looking with dismay at my body physically changing before my eyes... Whew!
Are we having fun yet?
JJ
QUOTE
Estrogen is a gonadal/steroidal hormone. It is a derivative of the same hormone pre-cursors as Testosterone. However, it is the Follicle Stimulating Hormone versus the Luteinizing hormone which is responsible for the aromatization of Progesterone and other Androgens into Estrogen. These steroids are secreted by the theca interna and granulosa cells of the developing ovarian follical, corpus luteum or the placenta. Estrogens are also produced by aromatization of androgens in fat cells and in the skin.
QUOTE
The main source of estrogen after the cessation of ovarian function is the aromatization of adrenal androstenedione to estrone. Estrone can be subsequently converted to more potent estradiol. Whereas the primary site for this conversion is in the fat cells, it is now known that significant aromatization takes place in tissues such as the breast, brain, bone, coronary artery, and the endometrium.
So, estogen is made from androgens which in turn manufactured either in ovaries (premenopausal) or in adrenals (once gonadal androgens no longer avaiable). There is not difference which fat cell is used to aromatized estrogen: belly or tighs. We gain more belly fat is because we lose estrogen and our become androgen dominant with all expected side effects: abdominal obesity, hair loss, and facial hair growth, etc.
I believe that our metabolism changes, so we gain weight at menopause even eating same number of calories as before, and as we get older, it becomes a challenge to keep up with exercise regimen, even we need it now more than in our 20s.
So, it is a combination of factors. Of course, estrogen play major role, but I see many young women in their 20s and 30s, that resemble menopausal weight gain (pot belly), grow facial hair and have male balding pattern, but they are not even remotedly close to be menopausal. They just have hormonal imbalance, and it directly related to diet, exercise, and using BCP. it ia known fact that diet high in sugar, sodas, processed and junk food, and high calories linked to bel;ly fat gain and makes hormonal balance practically impossible.
JMO